Lavas from the Quaternary East and West Eifel volcanic fields in western Germany are among the youngest volcanic products of the Central European Volcanic Province (CEVP). In a comprehensive approach, we report Sr-Nd-Pb-Os isotope as well as major and trace element data for 59 samples covering Quaternary Eifel volcanism. In accord with previous studies, all lavas are SiO2-undersaturated including primitive basanites, melilitites, and nephelinites as well as phonolites. In the West Eifel Field (WEVF), Sr–Nd–Pb compositions of the younger ONB-suite lavas are similar to FOZO or the EAR. Conversely, older (700 to 80 ka) F-suite lavas in the WEVF and from the entire East Eifel Field (EEVF) tap a more enriched mantle component, as illustrated by more radiogenic Sr isotope compositions and variable Pb isotope compositions. Radiogenic isotope compositions of F-suite and EEVF lavas require the admixture of melts from lithospheric mantle sources. Elevated Nb/Ta and Lu/Hf in combination with variable Os isotope compositions indicate residual carbonated eclogite components as a possible source of CO2 in the lavas. The presence of a mantle plume can neither be confirmed nor excluded based on geochemical data alone. However, the absence of W isotope anomalies together with only moderately elevated He isotope compositions argue against a deep-rooted plume beneath the Eifel volcanic fields. Collectively, plume-like melt pulses that partially tap carbonated eclogite domains and interact to variable extents with the lithospheric mantle provide a viable model for the compositional spread of volcanism in the Eifel and elsewhere in the CEVP.