Arc environments are Au-endowed and it has been long hypothesized that Au mobilization during slab dehydration could affect mantle composition and arc Au-fertility. Here, we determine Au-mobility during prograde high pressure-low temperature metamorphism of both metavolcanic and metasedimentary rocks from the islands of Santorini, Ios, Naxos and Syros (Greece). These have sustained peak metamorphism from greenschist to upper-blueschist/eclogite facies, allowing determination of large-scale Au-mobility within the subduction zone. Gold is significantly mobilized by fluids at the blueschist-eclogite facies. Mélange zones at the slab-mantle interface provide a unique opportunity to understand the fate of Au in the mantle. In these zones Au shows heterogeneous concentration but is not enriched, implying only partial retention in the mélange and efficient Au mobilization across slab-mantle interface. Furthermore, mélange zones contribute to the slab component inherent to arc magmatism and their intrinsically complex lithology as well as heterogenous Au concentration appears to play a role on arc magmatism Au-fertility.