Various proxy records have suggested widespread permafrost degradation in northern high latitudes during interglacial warm climates, including the mid Holocene (MH, 6000 years before present) and the last interglacial (LIG, 127 ka BP), and linked this to substantially warmer high-latitude climates compared to the pre-industrial period (PI). However, most Earth system models suggest only modest warming or even slight cooling in terms of annual mean surface temperatures during these interglacials. Here, we combine paleo permafrost reconstructions derived from speleothem and pollen records with paleoclimate simulations of the AWI-ESM-2.5 climate model and the CryoGridLite permafrost model to investigate the ground thermal regime and freeze-thaw dynamics in northern high-latitude land areas during the MH and the LIG. The simulated paleo permafrost extents are broadly in agreement with proxy contrainsts from speleothems. The simulations further revealed that not only changes in mean temperatures, but also the enhanced seasonal temperature amplitude due to a different orbital forcing have driven permafrost and ground ice dynamics during past interglacial climates. Our results provide an additional explanation of reconstructed periods of marked permafrost degradation in the past, which was driven by deep surficial thaw during summer, while colder winters allowed for permafrost persistence in greater depths. Our findings suggest that past interglacial climates have limited suitability as analogues for future permafrost thaw trajectories, as rising mean temperatures paralleled by decreasing seasonal amplitudes expose the northern permafrost region to magnitudes of thaw that are likely unprecedented since at least Marine Isotope Stage 11c (about 400 ka BP).