The application of finely ground silicate minerals to croplands and forests, with the aim of enhancing the rate of natural CO2 consuming weathering reactions, is receiving attention as a part of climate change mitigation strategies. Yet considerable uncertainty surrounds the quantification of CO2 removal associated with Enhanced Weathering, and its potential efficacy remains undemonstrated outside of the laboratory. Here, I discuss how the geochemical insights garnered from decades of natural weathering studies provide a pathway towards a strategy for ‘Monitoring, Reporting and Verification’ of CO2 sequestration. These natural weathering studies have also produced an understanding of what limits silicate weathering in different settings, which can be used to shed light on how deployment strategies, and specifically application sites, can be optimised.