Widespread exhumation and uplift affected Central Europe in Late Cretaceous to Paleogene time (e.g. Kley and Voigt, 2008, Geology, 36, 839-842). The area involved includes thrust-related basement uplifts and inverted Mesozoic basins and extends at least from the Rhenish Massif to the Bohemian Massif and from the Black Forest/Vosges to the North German Basin. Exhumation and basin inversion started at approx. 95 Ma based on stratigraphic constraints (Voigt et al. 2021, Solid Earth, https://se.copernicus.org/preprints/se-2020-188), well in line with ZHe cooling data (e.g. von Eynatten et al. 2019, International Journal of Earth Sciences, 108, 2097-2111). Late Cretaceous SW-NE directed basement thrusting (e.g. Harz Mountains, Thuringian Forest, Flechtingen High) peaked around 85 to 70 Ma. Thermochronological data (AFT, AHe) from the Triassic uplands between the basement highs reveal km-scale exhumation of a wider region, at least 250-300 km across, suggesting long-wavelength domal uplift (von Eynatten et al. 2021, Solid Earth, 12, 935-958). This domal uplift is dated slightly later at 75 to 55 Ma and calls for a separate mechanism superimposed on the Late Cretaceous compressional event. Based on timing, spatial extent of the doming area and thickness of eroded strata (3-4 km), possible mechanisms are evaluated for their contribution to exhumation and uplift. While shortening and crustal thickening may explain 50% of the domal uplift at most, upwelling asthenosphere driving dynamic topography appears capable of producing uplift and erosion of the required magnitude, wavelength and rate.